![]() ![]() A rare form of Darier disease is the hypertrophic / vegetating variant. ![]() Other characteristic forms of involvement are acrokeratosis verruciformis-like lesions in the back of the hands, white and red streaks in nails, and lesions in mucous membranes and genitalia.Īpoptotic fragments resultin typical features of dyskeratosis such as corps ronds (pyknotic nucleus surrounded by a clear halo and large keratohyalin bodies in granular layer) and grains (flattened cells with cigar-shaped nuclei in horny layer). Lesions may be induced or exacerbated by stress, heat,or sweating and are susceptible to bacterial, viral and fungal infections. Patients exhibit crusted and keratotic yellow-brown papules and plaques concentrated in “seborrheic” areas such as scalp ́, forehead, ears, nasolabial folds, upper chest, back and supraclavicular fossae. Disease presentation peaks at puberty, however, some patients may show signs of disease only by the sixth or seventh decades of life. About 47% of patients do not show familial history and it has been explained by new mutations or incomplete penetrance. ![]() It is a rare disease that is usually transmitted in an autosomal dominant pattern. ![]() Impaired imbalance of calcium intracellular homeostasis results in the characteristic apoptosis of keratinocytes. HPV hybridization situ was negative.ĭarier disease is caused by impaired keratinocyte adhesion caused by inactivating mutations of SERCA2 –a type 2 sarcoendoplasmic reticulum CA2+-ATPase. All sampled areas showed the same pattern of parakeratosis, dyskeratosis (corps ronds and grains), suprabasal acantholysis and pseudoepitheliomatous hyperplasia with prominent anastomosing cords of elongated rete ridges (with a syringofibroadenoma silhouette). Extensive sampling showed no atypia and no invasive foci. The diagnosis in those biopsies as well as in the resected specimen was Darier disease, hypertrophic / vegetating type. Thus, the model will be scaled up and be available for implementation elsewhere.Previous biopsies from lesions elsewhere 27 years ago and along the years showed the same verruciform, pseudoepitheliomatouspattern, with no atypia. The outcome of this model will be brought to the attention of national and international policy makers, NGOs and other organized interest groups though scientific articles and forums, media and international partners. On the basis so obtained a model will be developed to combat cardiovascular diseases in slums in the most effective and efficient way. The outcomes of the interventions will subsequently be tested, during which, emphatically, there will be attention to costing and feasibility. The concrete approach of these two interventions will be developed on the basis of the analysis and evaluation of earlier projects, earlier studies and additional literature research. In addition a public awareness campaign to promote a healthy lifestyle will be introduced into the community. To this end two clinics will be fitted out with trained staff and necessary materials where patients suffering from high blood pressure may be treated and where others may have their blood pressure measured. In order to arrive at a suitable model for combating cardiovascular diseases in slums, the project will focus on the treatment of patients with risk factors for cardiovascular diseases and furthermore on changes of lifestyle among the general slum population aimed at preventing cardiovascular diseases in the future. ![]()
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